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Updated: Jun 22, 2025

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
Role of breastfeeding in disease prevention
Andrea C Masi1, Christopher J Stewart1
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Insights
Breastfeeding offers significant health benefits for infants and mothers, impacting long-term health and reducing disease risks. It also lessens societal healthcare costs, highlighting the importance of promoting global breastfeeding practices.
Area of Science:
- Immunology
- Public Health
- Nutritional Science
Background:
- Human milk contains bioactive factors crucial for infant development.
- Breastfeeding influences the infant microbiome and immune system maturation.
- Positive health outcomes are linked to breastfeeding for both infants and mothers.
Purpose of the Study:
- To review the health benefits of breastfeeding for infants and mothers.
- To discuss the societal impact of breastfeeding.
- To explore future recommendations for research and promotion.
Main Methods:
- A literature search was conducted using Medline.
- Relevant articles on breastfeeding benefits and societal impact were reviewed.
Main Results:
- Breastfeeding protects infants from infections and reduces risks of obesity, type 1 diabetes, and leukemia.
- Mothers experience benefits like reduced postpartum bleeding, depression, and lower long-term risks of chronic diseases.
- Societal benefits include reduced healthcare costs associated with morbidity and mortality.
Conclusions:
- Breastfeeding confers extensive health advantages across the lifespan for individuals and society.
- Further research is needed to elucidate mechanisms and promote global breastfeeding.
- Enhanced understanding and promotion of breastfeeding are vital for public health.
Abstract:
Human milk provides the infant with many bioactive factors, including immunomodulating components, antimicrobials and prebiotics, which modulate the infant microbiome and immune system maturation. As a result, breastfeeding can impact infant health from infancy, through adolescence, and into adulthood. From protecting the infant from infections, to reducing the risk of obesity, type 1 diabetes and childhood leukaemia, many positive health outcomes are observed in infants receiving breastmilk. For the mother, breastfeeding protects against postpartum bleeding and depression, increases weight loss, and long-term lowers the risk of type 2 diabetes, breast and ovarian cancer, and cardiovascular diseases. Beyond infants and mothers, the wider society is also impacted because of avoidable costs relating to morbidity and mortality derived from a lack of human milk exposure. In this review, Medline was used to search for relevant articles to discuss the health benefits of breastfeeding and its societal impact before exploring future recommendations to enhance our understanding of the mechanisms behind breastfeeding's positive effects and promote breastfeeding on a global scale.
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