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Advances in noncoding RNA in children allergic rhinitis
Shuman Li1, Hongtao Cui2, Huina Lu2
1Chongqing Medical University, Chongqing, China.
Insights
Noncoding RNAs (ncRNAs) are crucial in regulating gene expression and are linked to allergic rhinitis (AR) in children. Research highlights their roles in disease development and potential as therapeutic targets.
Area of Science:
- Pediatric Allergy and Immunology
- Molecular Biology
- Epigenetics
Background:
- Allergic rhinitis (AR) significantly impacts children's quality of life.
- Environmental allergens trigger inflammatory and immunological responses, altering gene expression.
- Epigenetic modifications, including noncoding RNAs (ncRNAs), are increasingly linked to allergy development.
Purpose of the Study:
- To review the significance and advancements of ncRNAs in pediatric allergic rhinitis.
- To explore the roles of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) in AR.
- To identify future research directions for ncRNA-based therapeutics and biomarkers.
Main Methods:
- Literature review utilizing PubMed and author expertise.
- Inclusion of high-quality, large-scale studies.
- Focus on microRNAs, long noncoding RNAs, and circular RNAs.
Main Results:
- Various ncRNA categories exhibit distinct yet interconnected functions.
- ncRNAs are integral components of complex gene regulatory networks.
- These molecules play active roles in the pathogenesis of allergic diseases.
Conclusions:
- ncRNAs are pivotal in the pathogenesis and progression of pediatric AR.
- Understanding ncRNA mechanisms offers potential for novel therapeutic strategies.
- Future research should focus on translating ncRNA discoveries into clinical applications for AR management.
Background:
A chronic condition that significantly reduces a child's quality of life is allergic rhinitis (AR). The environment and allergens that the body is regularly exposed to can cause inflammatory and immunological reactions, which can change the expression of certain genes Epigenetic changes are closely linked to the onset and severity of allergy disorders according to mounting amounts of data. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.
Methods:
Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized.
Results:
Recent findings indicate that various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks.
Conclusion:
This article demonstrates the significance and progress of ncRNAs in children's AR. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore.
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