Advances in noncoding RNA in children allergic rhinitis.

Area of Science:

• Pediatric Allergy and Immunology
• Molecular Biology
• Epigenetics

Background:

• Allergic rhinitis (AR) significantly impacts children's quality of life.
• Environmental allergens trigger inflammatory and immunological responses, altering gene expression.
• Epigenetic modifications, including noncoding RNAs (ncRNAs), are increasingly linked to allergy development.

Purpose of the Study:

• To review the significance and advancements of ncRNAs in pediatric allergic rhinitis.
• To explore the roles of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) in AR.
• To identify future research directions for ncRNA-based therapeutics and biomarkers.

Main Methods:

• Literature review utilizing PubMed and author expertise.
• Inclusion of high-quality, large-scale studies.
• Focus on microRNAs, long noncoding RNAs, and circular RNAs.

Main Results:

• Various ncRNA categories exhibit distinct yet interconnected functions.
• ncRNAs are integral components of complex gene regulatory networks.
• These molecules play active roles in the pathogenesis of allergic diseases.

Conclusions:

• ncRNAs are pivotal in the pathogenesis and progression of pediatric AR.
• Understanding ncRNA mechanisms offers potential for novel therapeutic strategies.
• Future research should focus on translating ncRNA discoveries into clinical applications for AR management.