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Causal relationship between Helicobacter pylori infection and IgA nephropathy: a bidirectional two-sample mendelian
Shuhui Jing1,2,3, Ling Lin1,2,3, Jiaxing Li4
1Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Renal Failure
|July 1, 2024
Summary
This study found no causal link between Helicobacter pylori (H. pylori) infection and IgA nephropathy (IgAN). Mendelian randomization analysis confirmed no evidence that H. pylori causes IgAN or that IgAN increases H. pylori infection risk.
Area of Science:
- Nephrology
- Gastroenterology
- Genetics
Background:
- IgA nephropathy (IgAN) is a common primary glomerulonephritis.
- Elevated serum Helicobacter pylori (H. pylori) antibody levels are observed in IgAN patients, but a causal role remains unclear.
Purpose of the Study:
- To investigate the potential causal relationship between H. pylori infection and IgA nephropathy (IgAN).
- To examine reverse causality, determining if IgAN influences the risk of H. pylori infection.
Main Methods:
- Utilized bidirectional two-sample Mendelian randomization (MR) analysis.
- Employed inverse variance weighted (IVW), MR-Egger, and weighted median methods for estimation.
- Selected seven common serum H. pylori antibodies as exposure factors.
Main Results:
- No statistically significant evidence of a causal relationship was found between H. pylori infection and IgAN.
- Reverse MR analysis also indicated no causal effect of IgAN on the risk of H. pylori infection.
Conclusions:
- H. pylori infection is unlikely to be a causal factor in the development of IgA nephropathy.
- IgA nephropathy does not appear to increase the susceptibility to H. pylori infection.
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