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Targeted Bias: The Next Swing at IL2 Therapy
Kayla R Kulhanek1,2, Anusha Kalbasi2,3,4
1Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, California.
Abstract:
Despite its long history of toxicity and limited efficacy, IL2 has re-entered the clinic as a companion to the recently FDA-approved tumor infiltrating lymphocyte therapy. In back-to-back articles, Moynihan and Kaptein introduce a new fusion protein that delivers a biased IL2 mutein to CD8 T cells. See related article by Moynihan et al., p. 1206 (6). See related article by Kaptein et al., p. 1226 (7).
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