Gallbladder cancer: Progress in the Indian subcontinent.

Area of Science:

• Hepatobiliary and Pancreatic Diseases
• Surgical Oncology

Background:

• Gallbladder cancer (GBC) is a prevalent biliary malignancy in India, Argentina, and Japan.
• Late detection due to nonspecific symptoms leads to poor patient outcomes.
• Significant research advances in hepatobiliary diseases exist globally, but GBC research requires more focus.

Purpose of the Study:

• To review the progress of gallbladder cancer research in India over several decades.
• To highlight Indian contributions to basic and clinical research in GBC.
• To address unanswered questions regarding GBC etiopathogenesis, early diagnosis, treatment, and prognostication.

Main Methods:

• Systematic review of publications on gallbladder cancer from India.
• Analysis of research output spanning several decades.
• Focus on both basic science and clinical research advancements.

Main Results:

• India, a major hub for GBC, has a substantial body of research.
• Publications cover various aspects including etiopathogenesis, diagnostics, and treatment strategies.
• The review synthesizes findings to showcase national progress in GBC research.

Conclusions:

• Continued research from high-burden countries like India is essential for improving GBC outcomes.
• Understanding national research progress is key to addressing GBC challenges.
• Further investigation into GBC is needed to improve early detection and patient survival.