Related Experiment Video

Updated: Jun 22, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.5K

Bidirectional relationship between C-reactive protein and depressive symptoms considering cumulative effect among

Ningxuan Zhao1, Lin Jiang1, Meijing Hu1

  • 1Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Frontiers in Psychiatry
|July 1, 2024
PubMed

Insights

Repeated episodes of elevated C-reactive protein (CRP) and depressive symptoms show a bidirectional link in older Chinese adults. Cumulative effects, not single instances, drive this association, suggesting dual anti-inflammatory and antidepressant strategies may be beneficial.

Area of Science:

  • Biomedical Science
  • Epidemiology
  • Psychiatry

Background:

  • Research on the bidirectional relationship between C-reactive protein (CRP) and depressive symptoms is limited in non-Western populations.
  • The cumulative effect of repeated episodes of CRP or depressive symptoms requires further investigation.

Purpose of the Study:

  • To examine the bidirectional association between CRP and depressive symptoms in Chinese adults.
  • To investigate the role of cumulative effects of repeated episodes on this relationship.

Main Methods:

  • Utilized data from the Chinese Health and Retirement Longitudinal Study (CHARLS).
  • Employed multivariate logistic regression for bi-directional analysis, considering single and successive determinations of CRP and depressive symptoms.
  • Adjusted for socio-demographic, behavioral, metabolic, and health status factors.

Main Results:

  • Single determinations of CRP or depressive symptoms showed non-significant results.
  • Two successive determinations revealed significant bidirectional associations.
  • Cumulative CRP elevations predicted subsequent depressive symptoms (OR=1.58), and cumulative depressive episodes predicted later CRP elevation (OR=1.26).

Conclusions:

  • Bidirectional associations between depressive symptoms and CRP are driven by cumulative effects in middle-aged and older Chinese adults.
  • Findings suggest potential benefits of combined anti-inflammatory and antidepressant interventions.
  • Sex-stratified analyses confirmed the robustness of these relationships.
Abstract

Keywords:
C-reactive proteinbi-directional relationshipscumulative effectdepressive symptomspopulation based

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

656
A New Method for Inducing a Depression-Like Behavior in Rats07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

20.9K

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
63
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
30
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
118.0K
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
96
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
76
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
237