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  1. Home
  2. Cardiopulmonary Exercise Variables And Their Association With Postoperative Morbidity And Mortality After Major Oesophagogastric Cancer Surgery-a Multicentre Observational Study.
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  2. Cardiopulmonary Exercise Variables And Their Association With Postoperative Morbidity And Mortality After Major Oesophagogastric Cancer Surgery-a Multicentre Observational Study.

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Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major

Malcolm A West1,2, Saqib Rahman1, Sandy Jack2,3

  • 1School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

BJA Open
|July 1, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
cardiopulmonary exercise testingfitnessmorbiditymortalityneoadjuvant cancer treatmentsoesophagogastric cancertumour outcomes

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Cardiopulmonary exercise testing (CPET) did not predict 1-year survival in oesophagogastric cancer patients. Some pre-treatment CPET variables predicted 3-year survival, but overall predictive precision was limited.

Area of Science:

  • Oncology
  • Cardiology
  • Surgery

Background:

  • Outcomes for oesophagogastric cancer surgery are often poor.
  • Cardiopulmonary exercise testing (CPET) is used for risk stratification, but evidence is conflicting.
  • This study investigates CPET's role in predicting outcomes for patients receiving neoadjuvant treatment.

Purpose of the Study:

  • To explore the relationship between CPET variables and postoperative outcomes in patients undergoing oesophagogastric cancer resection.
  • To assess the predictive value of CPET for 1-year and 3-year survival.
  • To identify specific CPET parameters that may correlate with survival in this patient population.

Main Methods:

  • A retrospective, multicentre pooled cohort study of 611 patients undergoing oesophagogastric cancer resection and CPET.
  • Comparison of oxygen uptake at peak exercise (VO2 peak) with 1-year survival.
  • Logistic regression analyses to assess relationships between patient/tumour characteristics, CPET variables, and outcomes (morbidity, 1- and 3-year survival).
  • Main Results:

    • No association was found between VO2 peak and 1-year survival.
    • Anaerobic threshold relative to ideal body weight was associated with 3-year survival in the overall cohort.
    • Pre-neoadjuvant treatment CPET variables, including anaerobic threshold and VE/VCO2 at anaerobic threshold, were associated with 3-year survival, but other CPET variables showed no association.

    Conclusions:

    • VO2 peak is not a reliable predictor of 1-year survival post-oesophagogastric cancer resection.
    • Tumour characteristics and major complications significantly impact survival.
    • While some pre-neoadjuvant CPET parameters show potential for predicting 3-year survival, the overall predictive precision of CPET in this context is limited.