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Related Concept Videos

Preventive Healthcare Services01:30

Preventive Healthcare Services

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Endoscopic Procedures II: Colonoscopy01:25

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Updated: Jun 22, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Improving colorectal cancer screening programs.

Oscar J Cordero1, Lucia Mosquera-Ferreiro2, Iria Gomez-Tourino2

  • 1Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. oscarj.cordero@usc.es.

World Journal of Gastroenterology
|July 1, 2024
PubMed
Summary
This summary is machine-generated.

Effective colorectal cancer screening requires improved participation. Novel blood, urine, or saliva tests, including immune biomarkers like sCD26, show promise for earlier detection and increased adherence in primary care settings.

Keywords:
BiomarkerColonoscopyColorectal cancerFecal hemoglobin immunodetectionImmunoscoresMortality ratesScreeningSoluble sCD26

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Area of Science:

  • Gastroenterology and Oncology
  • Biomarker Discovery
  • Public Health Policy

Background:

  • Colorectal cancer screening is crucial for reducing mortality, with colonoscopy as the gold standard but facing low adherence.
  • Current fecal tests improve accessibility but also suffer from low participation rates.
  • Emerging screening methods aim to increase adherence by offering diverse, convenient options.

Discussion:

  • New blood tests detecting circulating tumor DNA (ctDNA) show accuracy for cancer but are less sensitive for precancerous lesions compared to stool tests.
  • Immune system-related biomarkers, such as sCD26, are being explored for early colorectal cancer detection, potentially identifying disease before fecal blood is present.
  • The development of tests based on blood, urine, or saliva could facilitate earlier screening through routine primary care visits.

Key Insights:

  • Novel screening strategies are essential to overcome low participation rates in current colorectal cancer screening programs.
  • Blood-based biomarkers, including immune markers and ctDNA, offer potential for earlier and more accessible colorectal cancer detection.
  • Integrating new screening tests into primary healthcare could significantly broaden population reach and improve adherence.

Outlook:

  • Future colorectal cancer screening may involve a multi-test approach, leveraging the strengths of various biomarkers and sample types.
  • Expanding screening eligibility to younger age groups through accessible primary care tests is a key future direction.
  • Continued research into immune system interactions with cancer holds promise for developing highly sensitive and specific early detection biomarkers.