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Enteric neuropathy in diabetes: Implications for gastrointestinal function.

Mona Mohamed Ibrahim Abdalla¹

¹Department of Human Biology, School of Medicine, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia. monamohamed@imu.edu.my.

World Journal of Gastroenterology

|July 1, 2024

Summary

Diabetic complications include enteric neuropathy, affecting the gut nervous system (ENS) and causing gastrointestinal issues. Early detection and multidisciplinary management are key for diabetic patients with GI dysfunction.

Keywords:

Diabetes Diabetic neuropathy Enteric nervous system Enteric neuropathy Gastrointestinal Insulin resistance

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Area of Science:

Gastroenterology
Endocrinology
Neuroscience

Background:

Diabetes mellitus significantly impacts the enteric nervous system (ENS), crucial for gastrointestinal (GI) function.
Diabetic enteric neuropathy arises from neuronal/glial dysfunction, oxidative stress, and inflammation, causing GI motility disorders like gastroparesis.

Discussion:

This editorial examines the pathophysiology of diabetic enteric neuropathy.
It reviews advanced diagnostic tools for early identification of GI complications in diabetes.
Current and novel therapeutic strategies, including pharmaceuticals, diet, and neuromodulation, are discussed.

Key Insights:

Diabetes-induced enteric neuropathy disrupts ENS function, leading to significant GI problems.
Early diagnosis and intervention are critical for managing diabetic GI complications.
A comprehensive, multidisciplinary approach is essential for effective patient care.

Outlook:

Further research into therapeutic targets and neuromodulatory interventions is warranted.
Integrating specialized care can improve quality of life for diabetic patients with GI issues.
Addressing enteric neuropathy is vital for holistic diabetes management.