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  1. Home
  3. Differences In Genomic Alterations And Accumulations Of Heavy Metals Between Advanced Non-small Cell Lung Cancer Patients With And Without Bone Metastasis.
  1. Home
  3. Differences In Genomic Alterations And Accumulations Of Heavy Metals Between Advanced Non-small Cell Lung Cancer Patients With And Without Bone Metastasis.

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Differences in Genomic Alterations and Accumulations of Heavy Metals Between Advanced Non-small Cell Lung Cancer

Zhong-Qiang Yao1, Hui-Hui Jiang2, Fei-Fei Wang1

  • 1Medical oncology, 3201 Hospital of Xi´an Jiaotong University Health Science Center, Hanzhong 723000, China.

Journal of Cancer
|July 1, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
bone metastasisheavy metalnon-small cell lung cancersomatic interactionssomatic mutationstissue

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Genomic alterations and serum heavy metal differences distinguish bone metastasis in non-small cell lung cancer (NSCLC) patients. Specific genes and metals like copper (Cu) and strontium (Sr) may identify high-risk individuals for bone metastasis.

Area of Science:

  • Oncology
  • Genomics
  • Environmental Health

Background:

  • Bone metastasis (BoM) significantly worsens outcomes for non-small cell lung cancer (NSCLC) patients.
  • Understanding the biological differences between NSCLC patients with and without BoM is crucial for targeted therapies and improved prognostics.

Purpose of the Study:

  • To systematically compare genomic alterations and serum heavy metal profiles in advanced NSCLC patients with and without bone metastasis.
  • To identify potential biomarkers for predicting or identifying patients at high risk for BoM.

Main Methods:

  • Next-generation sequencing (NGS) of tumor DNA from 42 NSCLC patients without BoM and 67 with BoM.
  • Inductively coupled plasma mass spectrometry (ICP-MS) to measure serum concentrations of 18 heavy metals.

Main Results:

  • Distinct sets of mutated genes were identified exclusively in patients with (e.g., NTRK1, FGFR1) or without BoM (e.g., BRAF, GNAS).
  • Significantly higher serum concentrations of copper (Cu) and strontium (Sr) were observed in patients with BoM.
  • Correlations were found between specific heavy metals and between gene mutations (EGFR, TP53) and heavy metals (Co, Cd).

Conclusions:

  • Advanced NSCLC patients with BoM exhibit unique genomic alterations, somatic interactions, and serum heavy metal profiles compared to those without BoM.
  • Serum levels of Cu and Sr may serve as potential indicators for identifying NSCLC patients at high risk for bone metastasis.