Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Circular RNA hsa_circ_0005927 is downregulated in gastric cancer (GC) and associated with poorer survival. It shows potential as a biomarker for early GC detection and may regulate invasion and metastasis.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Circular RNAs (circRNAs) are increasingly recognized for their roles in cancer development.
- The specific function and clinical relevance of hsa_circ_0005927 in gastric cancer (GC) remain largely unexplored.
- This study aimed to elucidate the mechanism and clinical significance of hsa_circ_0005927 in GC invasion and metastasis.
Purpose Of The Study
- To investigate the biological function of hsa_circ_0005927 in gastric cancer.
- To evaluate the clinical significance of hsa_circ_0005927 as a diagnostic and prognostic biomarker for GC.
- To explore the molecular mechanisms underlying the role of hsa_circ_0005927 in GC invasion and metastasis.
Main Methods
- Quantification of hsa_circ_0005927 in GC tissues, plasma, and gastric juice.
- Correlation analysis with clinicopathological parameters, survival analysis (Kaplan-Meier), and nomogram construction.
- In vitro assays for cell proliferation, migration, and invasion; nucleoplasmic separation for cellular localization.
- miRNA target prediction, transcriptome sequencing, and bioinformatics analysis for downstream gene identification and pathway enrichment.
Main Results
- Hsa_circ_0005927 expression was downregulated in high-grade intraepithelial neoplasia and GC tissues.
- Lower hsa_circ_0005927 levels correlated with advanced metastasis, reduced overall survival, and disease-free survival.
- Plasma hsa_circ_0005927 showed potential for early GC detection with 52.38% sensitivity and 76.19% specificity.
- Bioinformatics analysis identified 421 downstream target genes involved in pathways crucial for gastric carcinogenesis and metastasis, with GUCY1A2 and STK32A linked to immune infiltration.
Conclusions
- Hsa_circ_0005927 acts as a tumor suppressor in gastric cancer, inhibiting invasion and metastasis.
- Hsa_circ_0005927 is a promising biomarker for early gastric cancer screening.
- The findings provide insights into the molecular mechanisms of circRNAs in gastric cancer progression and immune response.
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