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Updated: May 26, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Rapidly progressing pediatric Lupus with Diffuse Alveolar Hemorrhage and CNS involvement
Mahdieh Vahedi1,2, Reza Nejad Shahrokh Abadi3, Abdolreza Malek1,2
1Department of Pediatrics, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Insights
Pediatric Systemic Lupus Erythematosus (SLE) can present subtly and worsen rapidly. Early, aggressive evaluation is crucial for children with non-responsive or deteriorating symptoms, especially those with pulmonary involvement.
Area of Science:
- Pediatric Rheumatology
- Pulmonology
- Autoimmune Diseases
Background:
- Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with diverse organ manifestations.
- Pulmonary involvement in pediatric SLE is rare but can be life-threatening.
- Prompt diagnosis and treatment are critical for managing SLE complications.
Key Clinical Message:
Systemic Lupus Erythematosus (SLE) can have an insidious onset and a fatal prognosis in children. Patients presenting without typical signs of SLE should undergo further evaluation if they are not responding to the initial diagnosis and treatment. This is especially true for patients with rapidly progressing symptoms and deterioration in spite of treatment.
Abstract:
Pediatric Systemic Lupus Erythematosus is a chronic autoimmune disorder with various organ involvement pulmonary involvement in the course of this disorder is a rare yet potentially life-threatening complication. In this case report we highlight the findings of a 16-year-old girl acutely and initially presenting with cough and fever, eventually complicating to diffuse alveolar hemorrhage and gradual loss of consciousness. Although the patient was started on immunosuppressive treatment after the diagnosis of lupus, based on renal and hematological impairment, was made and initially responded, she eventually deteriorated.
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