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Related Experiment Video

Updated: Jun 22, 2025

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Toxic Thyroid Adenoma Presenting as Apathetic Hyperthyroidism: A Case Report.

Mina Hanna1, Bo Sun1, Ravindraprasad Shekarappa2

  • 1Medicine, Trinity School of Medicine, Warner Robins, USA.

Cureus
|July 1, 2024
PubMed
Summary
This summary is machine-generated.

A toxic thyroid adenoma, a benign nodule, caused thyrotoxicosis in an elderly male presenting with fatigue and muscle cramps. The condition was successfully treated with methimazole, restoring normal thyroid function.

Keywords:
apathetic hyperthyroidismbenign adenomahyperfunctioning nodulehypothalamic-pituitary-thyroid axistoxic thyroid adenoma

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Area of Science:

  • Endocrinology
  • Nuclear Medicine

Background:

  • The thyroid gland regulates bodily homeostasis via the hypothalamic-pituitary-thyroid (HPT) axis.
  • Toxic thyroid adenomas are benign nodules causing thyrotoxicosis, often presenting with subtle or non-specific symptoms.

Observation:

  • An 81-year-old male with fatigue and muscle cramps underwent a PET scan for unrelated reasons.
  • Incidental finding of increased thyroid uptake on PET scan prompted further investigation.

Findings:

  • Diagnosis of toxic thyroid adenoma confirmed.
  • Patient's symptoms resolved with methimazole treatment, achieving a euthyroid state.

Implications:

  • Highlights the role of incidental findings in PET scans for diagnosing endocrine disorders.
  • Demonstrates effective management of toxic thyroid adenoma with methimazole.