Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Adult Stem Cells01:33

Adult Stem Cells

28.5K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
28.5K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Anatomy of the Intestines01:23

Anatomy of the Intestines

71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
Stem Cell Niche01:26

Stem Cell Niche

5.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum Level of Lactate Dehydrogenase is Associated with Cardiovascular Disease Risk as Determined by the Framingham Risk Score and Arterial Stiffness in a Health-Examined Population in China.

International journal of general medicine·2022
Same author

Cost-Effectiveness Analysis of Camrelizumab Plus Chemotherapy vs. Chemotherapy Alone as the First-Line Treatment in Patients With IIIB-IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Without EGFR and ALK Alteration from a Perspective of Health - Care System in China.

Frontiers in pharmacology·2022
Same author

Analysis of Gut Microbiota in Patients with Coronary Artery Disease and Hypertension.

Evidence-based complementary and alternative medicine : eCAM·2022
Same author

Degradation of Formaldehyde over MnO<sub>2</sub>/CeO<sub>2</sub> Hollow Spheres: Elucidating the Influence of Carbon Sphere Self-Sacrificing Templates.

ACS omega·2022
Same author

Radical trifunctionalization of hexenenitrile <i>via</i> remote cyano migration.

Chemical communications (Cambridge, England)·2021
Same author

The Systematic Landscape of Nectin Family and Nectin-Like Molecules: Functions and Prognostic Value in Low Grade Glioma.

Frontiers in genetics·2021

Related Experiment Video

Updated: Jun 22, 2025

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation
06:40

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation

Published on: April 1, 2021

4.9K

Gut microbiota modulating intestinal stem cell differentiation.

Lin He1, Chen Zhu2, Xiang-Feng Zhou1

  • 1Department of Alcohol and Drug Dependence Treatment, The Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China.

World Journal of Stem Cells
|July 1, 2024
PubMed
Summary
This summary is machine-generated.

Intestinal stem cells (ISCs) regulate gut inflammation, but uncontrolled proliferation can lead to cancer. Gut microbes and their metabolites influence ISC behavior, offering potential therapeutic targets for enteropathies.

Keywords:
Gut microbiotaGut stem nicheIntestinal stem cellsMicroenvironmentProbiotics

More Related Videos

Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research
10:39

Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research

Published on: April 7, 2023

8.1K
Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

8.6K

Related Experiment Videos

Last Updated: Jun 22, 2025

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation
06:40

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation

Published on: April 1, 2021

4.9K
Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research
10:39

Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research

Published on: April 7, 2023

8.1K
Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

8.6K

Area of Science:

  • Gastroenterology and Microbiology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Intestinal stem cells (ISCs) are crucial for repairing gut epithelial damage during inflammation.
  • Disordered ISC proliferation can lead to cancerous transformations.
  • The gut microbiota continuously interacts with ISCs.

Discussion:

  • Microbiota metabolites modulate ISC proliferation via transcription factors.
  • Differentiated colonocytes in a steady state degrade these metabolites, protecting ISCs.
  • This interaction highlights a delicate balance between regeneration and cancer prevention.

Key Insights:

  • Gut microbiota metabolites play a significant role in regulating ISC proliferation and differentiation.
  • A dysregulated balance can promote inflammation or cancer development.
  • Colonocytes act as a protective barrier against excessive microbial metabolite signaling.

Outlook:

  • Targeting gut flora and their metabolites presents a promising therapeutic strategy for enteropathies.
  • Future research can focus on manipulating microbial metabolites to control ISC behavior.
  • This approach could lead to novel treatments for inflammatory and cancerous gut conditions.