Artificial intelligence in knee osteoarthritis: A comprehensive review for 2022

The aim of this literature review is to yield a comprehensive and exhaustive overview of the existing evidence and up-to-date applications of artificial intelligence for knee osteoarthritis.

A literature review was performed by using PubMed, Google Scholar, and IEEE databases for articles published in peer-reviewed journals in 2022. The articles focusing on the use of artificial intelligence in diagnosis and prognosis of knee osteoarthritis and accelerating the image acquisition were selected. For each selected study, the code availability, considered number of patients and knees, imaging type, covariates, grading type of osteoarthritis, models, validation approaches, objectives, and results were reviewed.

395 articles were screened, and 35 of them were reviewed. Eight articles were based on diagnosis, six on prognosis prediction, three on classification, three on accelerated image acquisition, and 15 on segmentation of knee osteoarthritis. 57% of the articles used MRI, 26% radiography, 6% MRI together with radiography, 6% ultrasonography, and 6% only clinical data. 23% of the articles made the computer codes available for their study, and 26% used clinical data. External validation and nested cross-validation were used in 17% and 14% of articles, respectively.

The use of artificial intelligence provided a promising potential to enhance the detection and management of knee osteoarthritis. Translating the developed models into clinics is still in the early stages of development. The translation of artificial intelligence models is expected to be further examined in prospective studies to support clinicians in improving routine healthcare practice.