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Microbiome-driven anticancer therapy: A step forward from natural products

Yunxuan Guan1, Di Wu1, Hui Wang1

  • 1State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China.

Mlife
|July 1, 2024
PubMed

Insights

The human microbiome influences cancer development and treatment. Natural products offer a promising approach to enhance anticancer therapies by targeting these microbes.

Area of Science:

  • Oncology
  • Microbiology
  • Pharmacology

Background:

  • The human microbiome is recognized as a key factor in cancer development and progression.
  • Microbiome manipulation is a promising strategy to enhance anticancer therapies.

Purpose of the Study:

  • To review the molecular mechanisms of microbiome involvement in cancer.
  • To highlight the potential of natural products in cancer prevention and treatment.
  • To discuss future directions for microbiome-based cancer therapies.

Main Methods:

  • Literature review of current research on the human microbiome and cancer.
  • Analysis of molecular mechanisms linking microbiome and cancer progression.
  • Evaluation of natural products as therapeutic adjuvants.

Main Results:

  • The human microbiome plays a critical role in cancer development and progression.
  • Natural products can be utilized to modulate the microbiome for improved anticancer outcomes.
  • Targeted strategies involving natural products show potential as adjuncts to chemotherapy and immunotherapy.

Conclusions:

  • Modulating the human microbiome holds significant promise for cancer prevention and treatment.
  • Natural products offer a viable avenue for developing targeted cancer therapies.
  • Further research is needed to fully explore the therapeutic potential of microbiome modulation in oncology.
Keywords:
anticancercancerchemotherapyimmunotherapymicrobiota

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