Related Experiment Video
Updated: Jul 25, 2026

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
Published on: January 17, 2018
[Two Cases of Behcet's Disease-Like Syndrome with Gene Deficiency in ELF4]
Nan Wang1,2,3, Yongmei Xie1,2, Zhiling Wang1,2
1( 610041) Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Abstract:
The patient 1, a 13-year-old boy, was admitted due to "recurrent oral ulcers for 3 years, abdominal pain for 8 months, and perianal ulcers for 10 days"; The patient 2, a 3-year-old boy, was admitted due to "recurrent abdominal pain, diarrhea, and fever for over 3 months". Genetic testing of both patients revealed "deficiency in ELF4, X-linked" (DEX), and the patients were diagnosed with Behcet's disease-like syndrome due to deficiency in ELF4, accordingly. The patient 1 was successively given intravenous methylprednisolone pulses and oral prednisone and mesalazine for symptomatic treatment. The patient 2 was successively treated with corticosteroids combined with enteral nutrition, as well as oral mercaptopurine. Subsequently, both patients showed improvements in symptoms and were discharged.
Related Concept Videos
Pedigree Analysis
Pleiotropy
Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can exist in...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Inflammatory Bowel Disease III: Crohn's Disease

