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Recent advances on thermosensitive hydrogels-mediated precision therapy.

Hao Chen1, Jiangmei Xu2, Jiangwei Sun3

  • 1Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Anhui Medical University, Hefei 230032, China.

Asian Journal of Pharmaceutical Sciences
|July 1, 2024
PubMed
Summary

Sprayable thermosensitive hydrogels offer advanced precision therapy by optimizing drug delivery. These smart materials act as scaffolds and reservoirs, enhancing treatment efficacy for various diseases.

Keywords:
InjectablePrecision therapySprayableStimuli-responsiveThermosensitive hydrogels

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Precision therapy aims for optimal drug concentration at target sites, increasing efficacy and reducing side effects.
  • Thermosensitive hydrogels, which transition from sol to gel with temperature changes, are emerging as promising platforms for drug delivery and tissue engineering.

Purpose of the Study:

  • To review the recent advancements in thermosensitive hydrogels for precision therapy.
  • To explore their mechanisms, components, and diverse biomedical applications.

Main Methods:

  • Literature review of state-of-the-art developments in thermosensitive hydrogels.
  • Analysis of their thermo-gelling mechanisms and material components.
  • Investigation of applications in wound healing, anti-tumor therapy, osteogenesis, and other diseases.

Main Results:

  • Thermosensitive hydrogels can be formulated as sprayable or injectable solutions that gel at body temperature.
  • They serve as versatile scaffolds for cell growth and controlled drug release reservoirs.
  • Applications span wound healing, cancer treatment, bone regeneration, and treatment of periodontal, sinonasal, and ophthalmic conditions.

Conclusions:

  • Thermosensitive hydrogels represent a significant advancement in precision medicine, offering tailored drug delivery and therapeutic strategies.
  • Their unique properties facilitate innovative treatments across a spectrum of biomedical fields.
  • Future trends indicate continued development and expanded clinical translation for these advanced materials.