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A Protocol for Analyzing Hepatitis C Virus Replication
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A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

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Socio-demographic association with confirmed hepatitis C virus infection: A cross-sectional analysis from a teaching

Mithu Medhi1, Aparna Sonowal2, Pranjal Sonowal3

  • 1Department of Microbiology, Kokrajhar Medical College, Rangalikhata, Assam, India.

Journal of Family Medicine and Primary Care
|July 1, 2024
PubMed

Insights

Hepatitis C virus (HCV) infection affects 24.4% of screening-positive individuals. Prevention and early detection are crucial due to the lack of an effective vaccine and risk of severe complications.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma.
  • HCV infection is the most common chronic blood-borne illness globally.
  • Effective vaccines for HCV are currently unavailable, underscoring the need for prevention and early detection strategies.

Purpose of the Study:

  • To determine the prevalence of confirmed Hepatitis C virus infection among screening-positive patients.
  • To identify risk factors associated with confirmed HCV infection in this population.

Main Methods:

  • 160 screening-positive Hepatitis C samples were analyzed using HCV RNA Real Time-PCR for confirmation.
  • Statistical analysis was performed to assess the association of vaccination status and risk behaviors with PCR positivity.

Main Results:

  • The prevalence of confirmed Hepatitis C among screening-positive patients was 24.4%.
  • Vaccination against Hepatitis A and B showed a significant association with PCR positivity (p<0.05).
  • Intravenous drug use and having multiple sex partners were significantly associated with PCR positivity (p<0.05).

Conclusions:

  • Early detection and prevention of Hepatitis C are critical due to its serious complications and lack of a vaccine.
  • Risk factors such as IV drug use and multiple sexual partners are linked to confirmed HCV infection.
  • Understanding these associations can inform targeted public health interventions for HCV prevention.
Abstract

Keywords:
Hepatitis CRT-PCRvaccination

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