Related Experiment Video
Updated: Jun 22, 2025
External Cephalic Version: Is it an Effective and Safe Procedure?
Published on: June 6, 2020
Role of prophylactic tranexamic acid in reducing blood loss during cesarean section: A double-blind
Nutan Sinha1, Sarita Rajbhar1, Pushpawati Thakur1
1Department of Obstetrics and Gynecology, AIIMS RAIPUR, Raipur, Chattisgarh, India.
Background:
Postpartum hemorrhage (PPH) is defined by the World Health Organization as blood loss of ≥500 mL within 24 h of delivery. Globally, hemorrhage accounts for 27.1% of maternal deaths, making it the leading direct cause of maternal death. PPH has been identified in more than two-thirds of reported hemorrhage-related deaths, causing 38% of maternal deaths in India. Tranexamic acid, an antifibrinolytic, has been used to control bleeding after PPH is identified.
Materials And Methods:
Antenatal women admitted for elective cesarean section were randomized into two arms: the case group (received one gram of tranexamic acid 20 min prior to skin incision) and the control group (received a placebo), each group consisting of 36 participants. Clinical Trials Registry - India (CTRI) registration number - CTRI/2021/02/031579.
Results:
The mean (±standard deviation [SD]) intraoperative blood loss in the case group was 241.25 (±67.83) mL, and in the control group, it was 344.92 (±146.67) mL (P = 0.001), while postoperative blood loss did not differ significantly between the groups (P = 0.1470). In terms of the difference in hemoglobin, there was a significant difference between the two groups (P = 0.001). No significant maternal or neonatal side effects were found.
Conclusion:
Preoperative tranexamic acid, when given in elective cesarean section, significantly reduces intraoperative blood loss.
