Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lateralization01:28

Lateralization

319
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
319
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

413
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
413
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

215
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
215
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

468
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
468
Association Areas of the Cortex01:21

Association Areas of the Cortex

5.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.2K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

1.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.

Behavioral neuroscience·2026
Same author

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy.

Nature cardiovascular research·2026
Same author

An iPSC-derived model for drug screening in cerebral small vessel disease.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025
Same author

Hyperactive 20<i>S</i> proteasome enhances proteostasis and ERAD in <i>C. elegans</i> via degradation of intrinsically disordered proteins.

Science advances·2025
Same author

Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes.

eLife·2025
Same author

Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.

ACS chemical biology·2025
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2025

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

4.0K

The Retrosplenial Cortical Role in Delayed Spatial Alternation.

Dev Laxman Subramanian1, Adam M P Miller1, David M Smith1

  • 1Department of Psychology, Cornell University, Ithaca, NY 14853.

Biorxiv : the Preprint Server for Biology
|July 1, 2024
PubMed
Summary
This summary is machine-generated.

The retrosplenial cortex (RSC) is vital for spatial memory. RSC neuron activity during delays encodes spatial information, crucial for task performance, especially with longer delays.

Keywords:
delay period firing patternsdelayed spatial alternationretrosplenial cortexspatial working memory

More Related Videos

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

6.9K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K

Related Experiment Videos

Last Updated: Jun 22, 2025

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

4.0K
Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

6.9K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Behavioral Neuroscience

Background:

  • The retrosplenial cortex (RSC) is recognized for its role in spatial cognition.
  • Previous research indicates the RSC is essential for spatial working memory tasks.
  • The precise mechanisms of RSC neuronal encoding during memory delays remain unclear.

Purpose of the Study:

  • To investigate how retrosplenial cortex (RSC) neurons encode spatial memory during delay periods.
  • To examine the impact of RSC lesions on spatial alternation performance with varying delay durations.

Main Methods:

  • Excitotoxic lesions of the RSC were induced in rats.
  • Rats performed a spatial alternation task with varied delay lengths.
  • Neuronal activity in the RSC was recorded during task performance.

Main Results:

  • RSC lesions significantly impaired spatial alternation, particularly with longer delays.
  • RSC neurons showed distinct firing patterns preceding left versus right trials during delays.
  • These differential firing patterns were absent preceding errors.
  • Many RSC neurons exhibited trial-start firing bursts that differentiated directional choices.

Conclusions:

  • RSC neuronal firing patterns during delay periods encode critical spatial working memory information.
  • These patterns are essential for successful spatial alternation performance.
  • RSC activity may also prime behavioral responses for spatial navigation.