Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fatigue01:21

Fatigue

180
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
180
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

2.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.0K
Mitochondrial Membranes01:45

Mitochondrial Membranes

9.9K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
9.9K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.3K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.3K
Mitochondria01:37

Mitochondria

12.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
12.1K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

756
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
756

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A feedback control for restraining autoimmune γδ T cells: reprogramming into ILC1s.

bioRxiv : the preprint server for biology·2026
Same author

When help is harm.

Science advances·2026
Same author

Pain Rehabilitation to Optimize Major Orthopaedic Trauma REcovery (PROMOTE) compared with routine care : a multicentre, parallel-group, randomized feasibility trial with an embedded qualitative study.

The bone & joint journal·2026
Same author

Loss of calcium-dependent phospholipase A2 contributes to multi-omic changes in mouse denervated skeletal muscle.

Physiological reports·2026
Same author

Gene transfer from NDM-5-producing and OXA-48-producing Enterobacter hormaechei ST79 on contaminated dicloxacillin capsules to other Enterobacterales in Europe, 2020-23: a retrospective, observational, molecular epidemiological study.

The Lancet. Microbe·2026
Same author

Regulation of survival, growth, and metabolism by neuronal mTOR.

GeroScience·2026

Related Experiment Video

Updated: Jun 22, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.1K

Mitochondrial Dysfunction and Fatigue in Sjögren's Disease.

Biji T Kurien, John A Ice, Rebecca Wood

    Biorxiv : the Preprint Server for Biology
    |July 1, 2024
    PubMed
    Summary

    Mitochondrial dysfunction is linked to fatigue in Sjögren's disease (SjD). Dysfunctional mitophagy and reduced cellular respiration in T cells contribute to SjD symptoms, highlighting a key area for further research.

    More Related Videos

    Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
    09:40

    Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

    Published on: January 19, 2017

    11.7K
    Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
    08:19

    Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

    Published on: May 5, 2022

    2.4K

    Related Experiment Videos

    Last Updated: Jun 22, 2025

    Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
    08:56

    Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

    Published on: May 17, 2018

    9.1K
    Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
    09:40

    Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

    Published on: January 19, 2017

    11.7K
    Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
    08:19

    Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

    Published on: May 5, 2022

    2.4K

    Area of Science:

    • Immunology
    • Cellular Biology
    • Bioenergetics

    Background:

    • Sjögren's disease (SjD) is characterized by inflammation, dryness, and profound fatigue.
    • Mitophagy, the process of clearing damaged mitochondria, may be dysregulated in autoimmune disorders.
    • Persistently dysfunctional mitochondria can elevate reactive oxygen species, potentially contributing to disease pathology.

    Purpose of the Study:

    • To investigate the hypothesis that mitophagic processes are dysregulated in SjD.
    • To determine if dysfunctional mitochondria contribute to fatigue in SjD patients.
    • To assess the pathogenic extent and implications of dysregulated mitophagy in SjD.

    Main Methods:

    • Pan T cells were isolated from SjD patients and healthy controls.
    • Mitochondrial oxygen consumption rate (OCR) and glycolysis were measured using Seahorse.
    • Mitophagy transcriptional signatures were analyzed using whole-blood microarray data.

    Main Results:

    • SjD patients exhibited significantly lower basal OCR, ATP-linked respiration, maximal respiration, and reserve capacity compared to healthy subjects.
    • Lymphocytic mitochondria showed structural alterations in SjD.
    • Fatigue scores correlated with altered OCR in SjD patients.

    Conclusions:

    • Mitochondrial dysfunction is a significant issue in SjD, directly associated with patient fatigue.
    • Dysregulated mitophagy and impaired cellular respiration are implicated in SjD pathogenesis.
    • Further investigation into mitochondrial dysfunction in SjD is warranted.