Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Semiautomatic Quantification of <sup>99m</sup>Tc-TRODAT-1 SPECT Images in Patients With Idiopathic Parkinson's Disease.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2025
Same author

Thyroid Metastasis from Lung Adenocarcinoma.

Radiology. Imaging cancer·2023
See all related articles

Related Experiment Video

Updated: Jun 22, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K

Isolated Diffuse Bone Marrow Metastases From Signet-ring Cell Gastric Carcinoma.

Tsz-Kit Chow1

  • 1Tuen Mun Hospital, Clinic of Radiology and Nuclear Medicine, Nuclear Medicine Unit, Hong Kong, China.

Molecular Imaging and Radionuclide Therapy
|July 1, 2024
PubMed
Summary

A 71-year-old patient with signet-ring cell carcinoma experienced diffuse bone pain. Imaging revealed widespread metastatic lesions in the skeleton, confirmed by biopsy, leading to palliative care and eventual death.

Keywords:
18F-FDG PET/CTBone marrow metastasissignet-ring cell gastric carcinoma

More Related Videos

Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells
08:47

Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells

Published on: August 21, 2012

17.3K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.2K

Related Experiment Videos

Last Updated: Jun 22, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K
Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells
08:47

Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells

Published on: August 21, 2012

17.3K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.2K

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Signet-ring cell carcinoma is an aggressive subtype of gastric cancer.
  • Bone metastases are a common and debilitating complication of advanced cancers.
  • Early detection of skeletal metastases is crucial for effective palliative care.

Purpose of the Study:

  • To report a case of extensive skeletal metastases from signet-ring cell carcinoma.
  • To highlight the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in diagnosing diffuse bone involvement.
  • To illustrate the clinical course and outcome in such cases.

Main Methods:

  • A case study of a 71-year-old female patient with a history of signet-ring cell carcinoma.
  • Diagnostic imaging using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT).
  • Confirmation of metastatic disease via bone marrow biopsy.

Main Results:

  • The patient presented with bone pain and anemia.
  • FDG-PET/CT demonstrated diffuse, hypermetabolic sclerotic lesions throughout the axial and proximal appendicular skeleton.
  • Bone marrow biopsy confirmed metastatic carcinoma from a gastric primary.

Conclusions:

  • Signet-ring cell carcinoma can present with extensive, diffuse skeletal metastases.
  • FDG-PET/CT is a valuable tool for identifying widespread bone involvement in metastatic cancer.
  • The patient received palliative treatment but experienced rapid disease progression and mortality.