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Epigenetics in thyroid cancer: a bibliometric analysis.

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  • 1Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.

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Epigenetic research in thyroid cancer is rapidly expanding, revealing key molecular mechanisms and therapeutic targets. This study maps the field, highlighting trends and future directions for improved cancer treatment.

Keywords:
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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Epigenetics, modifications without DNA sequence changes, plays a vital role in thyroid cancer development and progression.
  • Understanding these epigenetic alterations is critical for advancing thyroid cancer research and treatment strategies.

Purpose of the Study:

  • To conduct a comprehensive bibliometric analysis of the thyroid cancer epigenetics research landscape.
  • To identify current trends, major research areas, influential contributors, and future research directions.

Main Methods:

  • Bibliometric analysis of Web of Science Core Collection data up to November 2023.
  • Utilized VOSviewer, CiteSpace, and R 'bibliometrix' for data analysis and visualization.
  • Identified key research themes, influential authors, institutions, and countries.

Main Results:

  • Significant growth in thyroid cancer epigenetics research over the last two decades.
  • Key themes include molecular mechanisms, biomarkers, thyroid cancer subtypes, therapeutics, technologies, and translational research.
  • Identified research hotspots indicating intensive study areas and potential breakthroughs.

Conclusions:

  • Provides an in-depth overview of the current state of epigenetics in thyroid cancer research.
  • Highlights the potential of epigenetic strategies as therapeutic options for thyroid cancer.
  • Offers insights for researchers and clinicians to advance understanding and treatment, emphasizing the need for future research.