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Updated: Jun 22, 2025

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
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Dysregulated ribosome quality control in human diseases

Tom McGirr1, Okan Onar1,2, Seyed Mehdi Jafarnejad1

  • 1Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, UK.

The FEBS Journal
|July 1, 2024
PubMed

Insights

Ribosome Quality Control (RQC) ensures accurate mRNA translation, vital for health. This review highlights RQC

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Precise mRNA translation is crucial for cellular homeostasis.
  • Dysregulated translation and abnormal translation events are linked to numerous diseases.
  • The importance of monitoring translation quality has been historically underestimated due to mRNA's transient nature.

Purpose of the Study:

  • To review recent advances in Ribosome Quality Control (RQC).
  • To emphasize the biological significance of RQC in maintaining homeostasis.
  • To highlight the implications of RQC in human diseases.

Main Methods:

  • Literature review of recent discoveries in RQC.
  • Analysis of RQC's role in homeostasis and disease prevention.

Main Results:

  • Recent discoveries reveal RQC as a key mechanism for monitoring mRNA translation quality.
  • RQC plays a critical role in maintaining cellular homeostasis.
  • RQC is implicated in the prevention of various human diseases.

Conclusions:

  • RQC is essential for ensuring the fidelity of mRNA translation.
  • Dysregulation of RQC contributes to disease pathogenesis.
  • Further research into RQC mechanisms holds promise for therapeutic strategies against diseases linked to translation errors.
Keywords:
RQCproteostasisribosome collisionsribosome quality controlribosome stalling

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