Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.0K
  1. Home
  3. Dna Methylation Of Bdnf And Rasa2 Genes Is Associated With Cognitive Function In Postmenopausal Women With Breast Cancer.
  1. Home
  3. Dna Methylation Of Bdnf And Rasa2 Genes Is Associated With Cognitive Function In Postmenopausal Women With Breast Cancer.

Related Experiment Video

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

8.6K

DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast

Myeong-Ga Cho1, Susan M Sereika2, Meredith H Cummings1

  • 1University of Pittsburgh.

Oncology Nursing Forum
|July 1, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

DNA methylation of brain-derived neurotrophic factor (BDNF) and RAS p21 protein activator 2 (RASA2) genes are linked to cognitive function. Specific gene methylation patterns correlate with both processing speed and perceived cognitive abilities in cancer patients.

Keywords:
DNA methylationbreast cancercognitionperceived cognitive functionprocessing speed

More Related Videos

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.0K
Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

2.6K

Related Experiment Videos

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

8.6K
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.0K
Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

2.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Oncology

Background:

  • Cognitive dysfunction is a common concern for cancer patients.
  • Understanding the molecular underpinnings of cognitive changes is crucial for developing interventions.

Purpose of the Study:

  • To investigate the association between DNA methylation of the BDNF and RASA2 genes and cognitive function in cancer patients.
  • To explore potential molecular mechanisms underlying cognitive changes in this population.

Main Methods:

  • Secondary analysis of baseline data from the Exercise Program in Cancer and Cognition Study.
  • Assessed DNA methylation of BDNF and RASA2 genes.
  • Measured processing speed (Grooved Pegboard, Digit Vigilance Test) and perceived cognitive function (Patient Assessment of Own Functioning Inventory).
  • Utilized regression analysis to determine associations.

    • Main Results:

    • Increased methylation of specific sites on the BDNF (cg21291635) and RASA2 (cg20247102) genes was associated with poorer processing speed.
    • Conversely, methylation of other sites on BDNF (cg20108357) and RASA2 (cg00567892) was linked to better perceived cognitive function.
    • These findings suggest distinct roles for gene methylation in different aspects of cognitive function.

    Conclusions:

    • DNA methylation patterns of BDNF and RASA2 genes are associated with both objective processing speed and subjective perceived cognitive function in cancer patients.
    • These associations suggest potential distinct molecular mechanisms influencing cognitive performance and perception.
    • Further research is warranted to elucidate these mechanisms and their implications for cancer survivorship care.