Related Experiment Video
Updated: Jun 22, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Personalized Amoxicillin Therapy in a Critically Ill Patient Undergoing Renal Replacement Therapy: A Grand Round
Philippine Garrigue1, Margot Reber2, Sophie Perinel-Ragey2
1Pharmacie à usage intérieur, CHU de Saint Etienne, Saint Etienne, France.
Background:
The case study discusses a complex scenario involving the use of amoxicillin in a critically ill patient undergoing intermittent renal replacement therapy.Severe infections are complicated by septic shock and organ failure, requiring urgent and effective antibiotic treatment.
Methods:
The patient's comorbidities, including obesity and acute kidney injury, required careful consideration of the amoxicillin dosing strategies.
Results:
Therapeutic drug monitoring is critical for dose adjustment during treatment.
Conclusions:
This case highlights the importance of a collaborative approach between clinicians and therapeutic drug monitoring consultants to optimize antibiotic therapy for critically ill patients with renal impairment.
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