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Natural Stilbenes: Their Role in Colorectal Cancer Prevention, DNA Methylation, and Therapy

Veronika Fialková1, Hana Ďúranová1, Petra Borotová1

  • 1AgroBioTech Research Centre, Slovak University of Agriculture, Nitra, Slovakia.

Nutrition and Cancer
|July 1, 2024
PubMed

Insights

Naturally occurring stilbenes show promise in reversing epigenetic alterations in colorectal cancer (CRC). Further research is needed to validate their potential in CRC prevention and treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Pharmacology

Background:

  • Colorectal cancer (CRC) exhibits resistance to conventional therapies like chemotherapy and radiation.
  • Side effects of current CRC treatments limit their efficacy.
  • Epigenetic modifications, particularly DNA methylation, play a crucial role in CRC development.

Purpose of the Study:

  • To review bioactive stilbenes as potential chemopreventive agents for CRC.
  • To explore the mechanisms by which stilbenes target DNA methylation machinery in CRC.
  • To highlight the need for further research into stilbene's role in CRC prevention and treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on stilbenes and CRC.
  • Focus on epigenetic mechanisms, specifically DNA methylation.
  • Analysis of molecular pathways modulated by stilbenes.

Main Results:

  • Stilbenes can modify aberrant DNA methylation, offering potential CRC therapeutic avenues.
  • Preclinical studies indicate effective DNA methylation modulation by stilbenes with minimal adverse effects.
  • Combination therapies involving stilbenes show promise for CRC treatment.

Conclusions:

  • Bioactive stilbenes represent a promising class of compounds for CRC chemoprevention.
  • Targeting DNA methylation machinery is a key mechanism of stilbene action in CRC.
  • More extensive research is required to confirm the clinical efficacy of stilbenes in CRC.

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