Models of sepsis-induced acute kidney injury

Area of Science:

• Nephrology
• Critical Care Medicine
• Translational Medicine

Background:

• Sepsis-induced acute kidney injury (S-AKI) is a severe complication of sepsis.
• The complex pathogenesis of S-AKI currently lacks specific effective treatments.
• Developing reliable preclinical models is essential for understanding S-AKI and advancing therapies.

Purpose of the Study:

• To review recent advancements in the development of S-AKI preclinical models.
• To provide guidance for selecting appropriate experimental models for S-AKI research.
• To support basic research and drug development efforts for S-AKI.

Main Methods:

• Literature review of recent studies on S-AKI model development.
• Analysis and synthesis of findings related to various S-AKI models.
• Comparative assessment of model suitability for different research objectives.

Main Results:

• Identified diverse preclinical models for S-AKI, each with unique advantages and limitations.
• Highlighted the importance of model selection based on research questions (pathogenesis vs. drug efficacy).
• Summarized key features and applications of current S-AKI models.

Conclusions:

• Appropriate selection of preclinical models is critical for advancing S-AKI research and therapeutic development.
• Further refinement of S-AKI models is needed to better mimic human disease.
• This review serves as a reference for researchers in the field of S-AKI.