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Updated: Jun 22, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis
Min Zhang1, Lixia Xia1, Wenbei Peng2
1Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Abstract:
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosinophils in MPE remains unclear. To investigate this, we conducted studies using both human samples and mouse models. Increased eosinophil counts were observed in patients with MPE, indicating that the higher the number of eosinophils is, the lower the LENT score is. In our animal models, eosinophils were found to migrate to pleural cavity actively upon exposure to tumor cells. Intriguingly, we discovered that a deficiency in eosinophils exacerbated MPE, possibly due to their anti-tumor effects generated by modifying the microenvironment of MPE. Furthermore, our experiments explored the role of the C-C motif chemokine ligand 11 (CCL11) and its receptor C-C motif chemokine receptor 3 (CCR3) in MPE pathology. As a conclusion, our study underscores the protective potential of eosinophils against the development of MPE, and that an increase in eosinophils through adoptive transfer of eosinophils or increasing their numbers improved MPE.
Insights
Eosinophils protect against malignant pleural effusion (MPE) in cancer. Increasing eosinophil numbers or transferring them improved MPE, highlighting their anti-tumor role.
Area of Science:
- Oncology
- Immunology
- Pulmonology
Background:
- Malignant pleural effusion (MPE) is common in advanced cancer with poor prognosis.
- Eosinophils are implicated in MPE development, but their precise role is unclear.
Purpose of the Study:
- To investigate the role of eosinophils in the development and progression of MPE.
- To explore the therapeutic potential of eosinophils in managing MPE.
Main Methods:
- Analysis of human MPE samples to correlate eosinophil counts with clinical scores (LENT score).
- Studies using mouse models to observe eosinophil migration and function in the pleural cavity.
- Investigation of the C-C motif chemokine ligand 11 (CCL11) and C-C motif chemokine receptor 3 (CCR3) pathways.
Main Results:
- Elevated eosinophil counts in MPE patients correlated with lower LENT scores.
- Eosinophils actively migrated to the pleural cavity in response to tumor cells in mouse models.
- Eosinophil deficiency exacerbated MPE, suggesting an anti-tumor effect mediated by microenvironment modification.
Conclusions:
- Eosinophils exhibit a protective role against MPE development.
- Enhancing eosinophil numbers, via adoptive transfer or other means, can improve MPE outcomes.
- Targeting eosinophil-related pathways may offer novel therapeutic strategies for MPE.
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