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Factors linked to prognosis in children with provisional tic disorder: a prospective cohort study

Fang Liu1, Chuangang Fan2, Baozhen Yao1

  • 1Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.

European Journal of Pediatrics
|July 1, 2024
PubMed

Insights

Provisional tic disorder (PTD) in children is often linked to longer disease duration, severe tics, and behavioral issues. These factors significantly impact remission rates and clinical management strategies for PTD.

Area of Science:

  • Pediatric Neurology
  • Child Psychiatry
  • Clinical Psychology

Background:

  • Provisional tic disorder (PTD) is a common condition in childhood.
  • Understanding prognostic factors is crucial for effective clinical management.

Purpose of the Study:

  • To identify factors associated with the prognosis of children diagnosed with provisional tic disorder (PTD).

Main Methods:

  • A prospective cohort study followed 259 children with PTD for one year.
  • LASSO logistic regression and path analysis were used to analyze remission predictors and mediators.

Main Results:

  • 30% of children achieved clinical remission within one year.
  • Disease duration >3 months, moderate/severe tic severity, and comorbid behavioral problems were significant predictors of remission.
  • Comorbid behavioral problems and recurrence partially mediated the relationship between tic severity and remission (37% mediation).

Conclusions:

  • Disease duration, tic severity, and behavioral problems are key prognostic factors in PTD.
  • Comorbid behavioral problems and recurrence play a mediating role in PTD prognosis.
  • Findings offer insights for improved clinical management of pediatric PTD.

Keywords:
Behavioral problemsPrognosisProvisional tic disorderRecurrenceRemission

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