Choroidal venous overload in Vogt‒Koyanagi‒Harada disease
Hoon Noh1, Seung Wan Nam1,2, Je Moon Yoon3
1Department of Ophthalmology, HanGil Eye Hospital, Incheon, Republic of Korea.
Eye (London, England)
|July 1, 2024
Summary
Choroidal venous overload is common in Vogt-Koyanagi-Harada (VKH) disease, appearing early and correlating with inflammation severity. These angiographic signs can help assess VKH disease status.
Area of Science:
- Ophthalmology
- Medical Imaging
- Rheumatology
Background:
- Vogt-Koyanagi-Harada (VKH) disease is a systemic inflammatory condition affecting ocular tissues.
- Choroidal venous overload is a suspected but not fully characterized feature of VKH disease.
Purpose of the Study:
- To investigate the prevalence and characteristics of choroidal venous overload in VKH disease.
- To compare these findings between early and late stages of the disease.
Main Methods:
- Retrospective review of multimodal imaging (fluorescein angiography and indocyanine green angiography) in 52 VKH patients and 24 controls.
- Assessment for signs of choroidal venous overload: perfusion delay, vascular hyperpermeability, dilated veins, and intervortex venous anastomosis (IVA).
Main Results:
- Choroidal venous overload signs were significantly more prevalent in VKH eyes than controls (p<0.05).
- These signs were more frequent in early-stage VKH disease and inversely related to disease duration.
- IVA was significantly associated with inflammation severity (total ICGA score).
Conclusions:
- Choroidal venous overload is an early manifestation of VKH disease.
- Angiographic signs of choroidal venous overload are valuable indicators for assessing VKH disease activity and progression.
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