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  11. A Critical Influence Of Hif-1 On Mmp-9 And Galectin-3 In Oral Lichen Planus

A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus

Hala H Hazzaa1, Marwa A M El Shiekh2, Osama Elkashty3

  • 1Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.

BMC Oral Health
|July 2, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Oral lichen planus (OLP) malignancy risk is linked to hypoxia-inducible factor-1 alpha (HIF-1), Galectin-3 (Gal-3), and matrix metalloproteinase-9 (MMP-9). These factors show significant correlations, suggesting a role in OLP carcinogenesis.

Area of Science:

  • Oncology
  • Oral Pathology
  • Molecular Biology

Background:

  • Oral lichen planus (OLP) is a potentially malignant disorder.
  • Inflammatory mediators play a role in OLP pathogenesis and oncogenesis.
  • Hypoxia-inducible factor-1 alpha (HIF-1), Galectin-3 (Gal-3), and matrix metalloproteinase-9 (MMP-9) are implicated in malignant transformation.

Purpose of the Study:

  • To investigate the expression of HIF-1, Gal-3, and MMP-9 in OLP tissue samples.
  • To determine the correlation between HIF-1, Gal-3, and MMP-9 expression in OLP.
  • To assess the potential role of these factors in the malignant transformation of OLP.

Main Methods:

  • Tissue samples from 20 OLP patients and 20 control subjects were analyzed.
  • Immunohistochemistry was used to detect the expression of HIF-1, Gal-3, and MMP-9.
Keywords:
Galactin-3Hypoxia-inducible factor 1aMMP-9Oral lichen planus

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  • Statistical analysis was performed to evaluate correlations between the studied factors.

    • Main Results:

    • Immunoreactivity for Gal-3, HIF-1α, and MMP-9 was observed in most epithelial cells of OLP tissues.
    • A strong positive correlation was found between HIF-1α and MMP-9 (r=0.9301, P<0.00001).
    • Significant positive correlations were also detected between Gal-3 and MMP-9 (r=0.7292, P=0.000264) and between Gal-3 and HIF-1α (r=0.5893, P=0.006252).

    Conclusions:

    • The findings support the hypothesis that hypoxia-adaptive pathways involving Gal-3 and MMP-9, regulated by HIF-1, are crucial in OLP carcinogenesis.
    • Elevated expression of HIF-1, Gal-3, and MMP-9 may serve as indicators of malignant potential in OLP.
    • This study provides evidence-based insights into the molecular mechanisms underlying OLP malignant transformation.