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Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy: A
Natthawadee Laokulrath1,2, Esther Chuwa3, Mihir Gudi2
1Department of Pathology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Introduction:
Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions.
Case Presentation:
We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40% of tumour cells).
Conclusion:
These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.
