Burden and Management of Multi-Drug Resistant Organism Infections in Solid Organ Transplant Recipients Across the...

Area of Science:

• Infectious Diseases
• Transplantation Medicine
• Microbiology

Background:

• Solid organ transplant (SOT) recipients are highly vulnerable to multidrug-resistant organisms (MDRO).
• Limited systematic data exists on MDRO prevalence and impact in SOT patients globally, particularly comparing high-income (HIC) and low- and middle-income countries (LMIC).
• Potential reporting biases and variations in screening, diagnostics, and therapeutics exist across different economic settings.

Purpose of the Study:

• To delineate the burden of key Gram-negative MDRO in SOT patients across HIC and LMIC.
• To provide a comprehensive overview of current diagnostic strategies for MDRO in SOT recipients.
• To review available therapeutic options for MDRO infections in this vulnerable population.

Main Methods:

• Systematic literature review focusing on Gram-negative MDRO in SOT recipients.
• Analysis of prevalence, morbidity, and mortality data stratified by country income level.
• Assessment of diagnostic and therapeutic resource availability.

Main Results:

• Gram-negative MDRO pose a significant threat to SOT recipients worldwide.
• Data gaps and potential biases exist in reporting MDRO epidemiology across HIC and LMIC.
• Variability in diagnostic capabilities and access to novel antimicrobial agents impacts patient outcomes.

Conclusions:

• Addressing the global challenge of MDRO in SOT recipients requires standardized surveillance and equitable access to diagnostics and treatments.
• Further research is needed to elucidate specific MDRO burdens and optimize management strategies in LMIC.
• Improved global collaboration is essential to combat the rising threat of antimicrobial resistance in transplantation.