Related Experiment Videos
Margination and emigration of leucocytes
Survey and Synthesis of Pathology Research
|January 1, 1985
Summary
Leukocyte margination and emigration in inflammation are distinct processes regulated by different stimuli. Tachyphylaxis may control peak neutrophil influx, while other factors regulate sustained low-grade influx.
Area of Science:
- Immunology
- Cell Biology
- Inflammation Research
Background:
- Leukocyte margination and emigration are key to inflammatory responses.
- Previous studies suggest distinct stimuli regulate these two processes.
- Recent findings on tachyphylaxis in skin lesions offer new insights.
Purpose of the Study:
- To compare tachyphylaxis with other regulatory mechanisms of acute inflammation.
- To propose a unified theory for leukocyte margination and emigration.
- To identify critical questions for resolving leukocyte migration mechanisms.
Main Methods:
- Literature review and comparison of existing data on leukocyte behavior in inflammation.
- Analysis of tachyphylaxis in relation to neutrophil chemotaxins and inflammatory mediators.
- Development of a theoretical model for leukocyte extravasation.
Main Results:
- Tachyphylaxis may regulate peak neutrophil influx, while chemotaxin inactivators and migration inhibition factors control sustained influx.
- Endothelial cell alterations are sufficient stimuli for margination.
- A general theory predicts selective margination onto endothelial acceptor molecules and extravasation via chemotactic stimuli.
Conclusions:
- A bipartisan model proposes non-specific inflammatory cell recruitment and specific immune cell recruitment.
- Tachyphylaxis characterizes inflammatory recruitment but not immune recruitment.
- Further research is needed on endothelial binding of chemotaxins, margination selectivity, and lymphocyte recirculation.