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Related Experiment Video

Updated: Jun 22, 2025

Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules

Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules

Published on: May 23, 2015

Why do a lung biopsy for benign lesions?

Luciano Cardinale¹, Domenico Basile², Thomas Fraccalini³

¹Unit of Radiology, San Luigi Gonzaga, University of Turin, Orbassano, Turin, Italy - luciano.cardinale@gmail.com.

Minerva Surgery

|July 2, 2024

Summary

Transthoracic needle biopsy of lung lesions can incidentally identify benign conditions. This study found 10% of biopsies revealed benign lesions, including hamartomas and granulomas, which can mimic lung cancer.

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Last Updated: Jun 22, 2025

Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules

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Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

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Published on: November 10, 2014

Area of Science:

Pulmonary Medicine
Diagnostic Imaging
Pathology

Background:

Transthoracic needle biopsy (TTNB) is standard for lung lesion diagnosis, with high accuracy for malignancy.
Literature often emphasizes malignant diagnoses, yet benign lesions are also incidentally found via biopsy.
Biopsies for presumed benign lesions occur due to unexpected findings or as a diagnosis of exclusion.

Purpose of the Study:

To determine the frequency and types of benign lung lesions diagnosed via TTNB.
To identify benign pathologies that may be misdiagnosed as lung cancer on imaging.

Main Methods:

Retrospective single-center study of CT-guided lung biopsies from 2015-2019.
Analysis of histological data from 969 patients.
Focus on benign lesions, detailing imaging features and differential diagnoses with malignancy.

Main Results:

Out of 969 biopsies, 93 (10%) revealed benign lesions.
Common benign pathologies mimicking lung cancer include hamartomas, granulomas, slow-resolving pneumonia, and cryptogenic organizing pneumonia.

Conclusions:

Benign lesions constitute a notable proportion of TTNB findings.
Understanding imaging characteristics of these benign lesions is crucial for accurate differential diagnosis with lung cancer.