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Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint
Sinjini Sarkar1,2, Ranita Pal3, Trisha Choudhury4
1Young Scientist -DHR, Department of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.
Indian Journal of Public Health
|July 2, 2024
Summary
Budding Uninhibited by Benzimidazoles 3 (BUB3) expression predicts chemotherapy response in ovarian cancer. Genetic variants in BUB3 impact treatment toxicity and patient quality of life.
Area of Science:
- Oncology
- Pharmacogenomics
- Molecular Biology
Background:
- Chemotherapy, particularly platinum and taxane compounds, causes significant toxicity in cancer patients.
- Pharmacogenomics offers a promising approach to personalize cancer treatment by predicting patient response and side effects.
- The spindle-assembly checkpoint (SAC) pathway is crucial for the cytotoxic activity of common chemotherapeutics.
Purpose of the Study:
- To investigate the role of Budding Uninhibited by Benzimidazoles 3 (BUB3), a SAC component, in advanced ovarian cancer.
- To evaluate BUB3 expression and genetic variants as potential predictive markers for paclitaxel-carboplatin chemotherapy response and toxicity.
Main Methods:
- Analysis of BUB3 expression levels in 80 advanced ovarian cancer patients.
- Genotyping of BUB3 genetic variants (rs11248416 and rs11248419).
- Correlation of BUB3 expression and polymorphisms with chemosensitivity, survival, and treatment-related toxicities.
Main Results:
- BUB3 expression correlated with chemosensitivity, indicating its potential as a predictive marker.
- High BUB3 expression was associated with an increased risk of poor survival.
- Specific BUB3 polymorphisms (rs11248416 and rs11248419) were significantly linked to chemotherapy toxicities.
- The rs11248416 polymorphism negatively impacted patients' physical quality of life.
Conclusions:
- BUB3 is a potential predictive biomarker for chemotherapy response in ovarian cancer.
- BUB3 genetic variants influence chemotherapy-induced toxicities and patient quality of life.
- Targeting BUB3 or its related pathways may offer strategies for personalized ovarian cancer treatment.
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