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T Helper Cells Producing Granulocyte-Macrophage Colony Stimulating Factor as a Risk Marker for Coronary Heart Disease

D Mou1, S Wu1, L Jiao1

  • 1Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.

Bulletin of Experimental Biology and Medicine
|July 2, 2024
PubMed

Insights

This study found higher levels of specific T helper cells and inflammatory cytokines in coronary heart disease (CHD) patients. These findings suggest potential new biomarkers for detecting CHD.

Area of Science:

  • Immunology
  • Cardiovascular Medicine

Background:

  • Coronary heart disease (CHD) involves abnormal immune cell aggregation in atherosclerotic plaques.
  • Understanding immune cell dynamics is crucial for CHD pathogenesis.

Purpose of the Study:

  • To identify abnormal T cell subtypes and inflammatory factors in patients with coronary heart disease.
  • To explore potential biomarkers for CHD detection.

Main Methods:

  • Flow cytometry was used to analyze T cell subtypes in peripheral blood from CHD patients (n=141) and healthy controls (n=46).
  • Plasma cytokine concentrations were quantified using multiplex assays.

Main Results:

  • CHD patients exhibited increased numbers of T helper cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF).
  • Elevated fractions of Th1 and Th17 cells were observed in CHD patients.
  • Higher plasma levels of IL-4, IL-5, IL-6, and IL-10 were detected in CHD patients compared to controls.
  • A correlation was found between the count of GM-CSF-producing T cells and CHD severity.

Conclusions:

  • Aberrant T cell populations and specific cytokine profiles are associated with coronary heart disease.
  • T cells producing GM-CSF may serve as a potential biomarker for CHD detection and severity assessment.

Keywords:
Th17ThGMcoronary heart diseasecytokinesinflammatory diseases

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