Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The extracellular matrix in development and in disease.

G R Martin, H K Kleinman

    Seminars in Liver Disease
    |May 1, 1985
    PubMed
    Summary

    Cellular interactions with extracellular matrix (ECM) components are crucial. Fibrotic matrix components can trigger irreversible tissue damage, but new methods aid in identifying disease-related matrix proteins.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Heavy sedation versus general anesthesia for pediatric invasive cardiology: a Grayer shade of blue versus a pinker shade of pale?

    Pediatric cardiology·2003
    Same author

    Combined immunosuppression with cyclosporine, rapamycin, and mycophenolate mofetil controls rejection with minimal nutritional impact in experimental small intestinal transplantation.

    Transplantation proceedings·2002
    Same author

    Ostrich ocular optics.

    Brain, behavior and evolution·2002
    Same author

    c-Myc regulates mammalian body size by controlling cell number but not cell size.

    Nature·2001
    Same author

    Tree-dimensional imaging of atrial septal occlusion device.

    Pediatric cardiology·2001
    Same author

    Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.

    The Journal of clinical investigation·2001

    Area of Science:

    • Cell Biology
    • Biochemistry
    • Pathology

    Background:

    • Cell-extracellular matrix (ECM) interactions are mediated by cell surface receptors.
    • Normal ECM components promote cellular functional competence.
    • Altered ECM in fibrotic conditions can drive pathological cellular changes.

    Purpose of the Study:

    • To explore the dual role of ECM components in cellular function and disease.
    • To elucidate mechanisms underlying prolonged fibrotic responses.
    • To highlight novel methods for identifying disease-associated ECM proteins.

    Main Methods:

    • Investigated cell-surface receptor interactions with ECM glycoproteins, collagens, and proteoglycans.
    • Postulated two types of matrix-induced cellular reactions: normal and fibrotic.
    • Utilized new techniques for identifying cellular and protein species in disease states.

    Main Results:

    • Normal ECM components induce functional competence in cells.
    • Fibrotic ECM components shift cellular activities, potentially leading to irreversible tissue damage.
    • Mechanisms exist that prolong and amplify fibrotic responses.

    Conclusions:

    • Cell-ECM interactions are critical regulators of tissue homeostasis and disease.
    • Fibrotic ECM remodeling can cause irreversible loss of tissue structure and function.
    • Emerging methodologies facilitate the identification of key ECM players in pathological conditions.

    Related Experiment Videos