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Updated: Jun 22, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Association of polymorphisms within P2RX4 with type 2 diabetes mellitus: a preliminary case-control study
Homa Noori1, Mahdi Majidpour2, Mahboobeh Sabeti Akbar-Abad3,4
1Department of Biology, Payame Noor University of Mashhad, Iran.
Objective:
Type 2 diabetes mellitus (T2DM) is a complex heterogenic metabolic with a wide range of etiology. Purinergic receptors have pivotal roles in different processes and are hypothesized to have roles in the pathogenesis of T2DM.
Materials And Methods:
Three hundred subjects affected by T2DM and 300 healthy subjects were genotyped by amplification refractory mutation system polymerase chain reaction (ARMS-PCR). SPSS V16.0 was recruited for statistical analysis.
Results:
The findings showed that the G allele of rs25644A > G increases the risk of T2DM in our population statistically (OR = 1.51, 95% CI = 1.14-1.99, p = 0.003). This allele in some genotype models, including the dominant model, caused an increase in the risk of T2DM. The interaction of genotypes between studied variants in the P2XR4 gene increased the risk of T2DM. Haplotype analysis showed that Ars1169727/Grs25644 haplotype caused an increase in the risk of T2DM.
Conclusions:
The findings suggest that rs25644A > G plays a role in our population's increased risk of T2DM.
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