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Published on: July 5, 2024
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Probiotics combination effectively improves constipation in pregnancy by modifying the gut microbiota composition.
1National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, 529927Nanchang University, Nanchang 330031, China P.R.
Beneficial Microbes
|July 2, 2024
Summary
Probiotics significantly improved constipation symptoms in pregnant women by restoring gut microbiota diversity. This intervention enhanced bowel regularity and stool consistency, offering a promising therapeutic option beyond diet and lifestyle changes.
Area of Science:
- Gastroenterology
- Microbiology
- Obstetrics
Background:
- Pregnancy constipation poses risks like miscarriage and preterm labor.
- Limited evidence exists on probiotics for pregnancy-related constipation.
Purpose of the Study:
- To assess the efficacy of probiotics in alleviating constipation during pregnancy.
- To investigate the impact of probiotics on intestinal microbiota composition in constipated pregnant women.
Main Methods:
- A study involving 29 healthy and 65 constipated pregnant women.
- Utilized Constipation Severity Scale (CSS) and Bristol Stool Scale (BSS) for symptom assessment.
- Employed 16S rRNA sequencing to analyze changes in gut microbiota.
Main Results:
- Probiotics improved CSS and BSS scores, increasing defecation frequency and improving stool characteristics.
- 16S rRNA sequencing showed restored intestinal microbiota diversity.
- Beneficial bacteria (Firmicutes, Actinobacteria, Faecalibacterium, Bifidobacterium) increased, while harmful bacteria (Bacteroidetes, Bacteroides, Prevotella) decreased.
Conclusions:
- Probiotics effectively relieve pregnancy constipation by enhancing gut microbiota diversity and restoring microbial balance.
- Probiotics demonstrate a stronger moderating effect than diet and lifestyle modifications for pregnancy constipation.
- Provides clinical data and theoretical basis for using probiotics in treating constipation during pregnancy.
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