Does a broad-spectrum cannabidiol supplement improve performance in a 10-min cycle ergometer performance-test?
Scott H Gillham1, Lynn Starke1, Lauren Welch1
1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
European Journal of Sport Science
|July 3, 2024
Summary
Daily cannabidiol (CBD) supplementation did not enhance cycling performance or alter perceived exertion in healthy adults. This study found no performance benefits from 3 weeks of broad-spectrum CBD use in a 10-minute cycling trial.
Area of Science:
- Exercise Physiology
- Nutritional Supplementation
- Cannabinoid Research
Background:
- Cannabidiol (CBD), a non-intoxicating phytocannabinoid, is investigated for potential anti-inflammatory and analgesic effects.
- Perceived pain can negatively impact exercise performance, making CBD a potential ergogenic aid.
- Limited research exists on CBD's direct impact on exercise performance metrics.
Purpose of the Study:
- To determine if 3 weeks of daily CBD supplementation improves 10-minute cycling performance.
- To assess the effects of CBD on physiological and perceptual responses during exercise.
- To evaluate the efficacy of broad-spectrum CBD as a performance-enhancing supplement.
Main Methods:
- A randomized, double-blind, placebo-controlled study involving 22 healthy participants.
- Participants received either 150 mg/day of oral CBD or a placebo for 3 weeks.
- Performance was assessed via a 10-minute cycling trial on a WattBike ergometer, measuring mean power, heart rate, blood lactate, and RPE.
Main Results:
- No significant differences in mean power output were observed between the CBD and placebo groups.
- No significant differences in heart rate, blood lactate, or ratings of perceived exertion were found between conditions.
- Three weeks of daily broad-spectrum CBD supplementation did not improve cycling performance or alter perceptual responses.
Conclusions:
- Daily supplementation with 150 mg of broad-spectrum CBD for 3 weeks does not enhance 10-minute cycling performance in healthy individuals.
- CBD supplementation did not significantly affect physiological markers or perceived exertion during the performance trial.
- Current evidence does not support the use of broad-spectrum CBD supplements for improving performance in this type of exercise modality.
Related Concept Videos
Dose-Response Relationship: Potency and Efficacy
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it produces...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...


