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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

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Modelling the innate immune system in microphysiological systems.

Michael J Rupar¹, Hannah Hanson¹, Stephanie Rogers¹

¹Hesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.

|July 3, 2024

Summary

This review details how microphysiological systems advance immune response modeling. These systems offer new insights into immune cell functions across human body systems, both individually and collaboratively.

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Area of Science:

Immunology
Systems Biology
Biotechnology

Background:

The immune system is complex, involving interactions across multiple human body systems.
Traditional modeling methods have limitations in capturing in vivo immune dynamics.

Purpose of the Study:

To critically review the evolution of immune response modeling.
To highlight the application and impact of microphysiological systems in this field.

Main Methods:

Review of scientific literature on immune response modeling.
Analysis of studies utilizing microphysiological systems for immune research.

Main Results:

Microphysiological systems have significantly enhanced the study of immune cell components and functions.
These systems provide a platform to model immune interactions within the context of whole human body systems.

Conclusions:

Microphysiological systems are pivotal in advancing our understanding of immune cell behavior.
This technology expands foundational knowledge and offers insights into collaborative immune functions.