Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations...

Area of Science:

• Oncology
• Pharmacology
• Natural Products

Background:

• Citrus fruit bioactive compounds are increasingly recognized for their anticancer potential.
• Naringenin demonstrates antioxidant and anticancer properties in numerous human and animal studies.
• Naringenin possesses pleiotropic anticancer effects, including modulating cell signaling and inhibiting growth factors.

Purpose of the Study:

• To review the anticancer potential of naringenin (NGE).
• To explore naringenin's pharmacological activities and mechanisms against various cancers.
• To assess naringenin's role in developing novel and safe anticancer medications.

Main Methods:

• Literature review of in vitro and in vivo studies.
• Analysis of naringenin's effects on cancer progression and related cellular processes.
• Examination of studies involving pure naringenin, nanoparticles, and combination therapies.

Main Results:

• Naringenin suppresses cancer progression and exhibits anti-inflammatory, antioxidant, and neuroprotective effects.
• Studies demonstrate naringenin's efficacy against colon, lung, breast, liver, and other cancers.
• Naringenin treatment, including nanoparticle formulations, aids in carcinogen inactivation.

Conclusions:

• Naringenin shows significant promise as a therapeutic agent in oncology.
• Its broad-spectrum anticancer activities and safety profile support its use in cancer treatment.
• Further research into naringenin-based therapies could lead to advanced anticancer drug development.