[Dynamics of blood glucose, serum insulin and lipids during the oral glucose tolerance test in hyperthyroidism]

Blood glucose, serum level of IRI, NEFA, total and HDL-cholesterol during oral loading with 100 g glucose were studied in 42 patients (37 females and 5 males), at an average age of 46,3, with various forms of hyperthyroidism. Diabetes mellitus was established in 3 patients, and in 10--reduced glucose tolerance. The basal insulinemia is increased in the patients with normal glucose tolerance (mean value 36,34 microU/ml), as compared with those with reduced tolerance (22,94 microU/ml). It manifested a moderate increase but slowed down reduction during the test. The insulin-glucose ratio, an indirect index for tissue insulin resistance, is four-fold increased as compared with the healthy. The total cholesterol and NEFA in the patients with normal and reduced glucose tolerance were with similar levels but during the test NEFA were more pronouncedly reduced in case of normal tolerance. The level of HDL-cholesterol in patients with reduced tolerance is lower (means +/- S = 0,77 +/- 0,42 mmol/l), though insignificantly, as compared with that of normal tolerance (1,03 +/- 0,4 mmol/l). The changes in triglycerides are but opposite: higher (2,21 +/- 0,67 mmol/l) with reduced and lower (1,74 +/- 1,46 mmol/l) in normal glucose tolerance. The differences in HDL-cholesterol and in triglycerides grow in the course of the test. The role of the altered lipid indices is discussed, particularly in reduced glucose tolerance, in the genesis of cardiac complications in hyperthyroidism.