Risk factors of postoperative complications and their effect on survival after laparoscopic gastrectomy for gastric cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Major complications after laparoscopic gastrectomy for gastric cancer significantly reduce patient survival. Charlson comorbidities and anastomosis type predict these complications, highlighting areas for improved patient outcomes.
Area Of Science
- Surgical Oncology
- Gastrointestinal Surgery
- Cancer Research
Background
- The impact of postoperative complications on long-term survival following laparoscopic gastrectomy (LG) for gastric cancer (GC) requires further clarification.
- Understanding these associations is crucial for improving patient prognosis and surgical strategies.
Purpose Of The Study
- To determine the incidence and identify risk factors for postoperative complications in patients undergoing LG for GC.
- To evaluate the influence of these complications on overall survival (OS) and disease-free survival (DFS).
Main Methods
- A retrospective analysis of 621 patients who underwent LG for gastric adenocarcinoma from March 2015 to December 2021.
- Complications were graded using the Clavien-Dindo classification; major complications were defined as Grade III or higher.
- Logistic regression and Cox proportional hazard models were employed to identify risk factors and assess survival impacts.
Main Results
- The overall complication rate was 17.6%, with major complications occurring in 5.3% of patients.
- Independent risk factors for major complications included a higher Charlson comorbidities index and specific anastomosis types (Billroth II vs. Billroth I).
- Major complications independently predicted reduced OS (HR 2.32) and DFS (HR 2.63), with tumor size, lymph node invasion, and T4a stage also impacting survival.
Conclusions
- Major complications following LG for GC occur in approximately 5.3% of cases.
- Charlson comorbidities index and anastomosis type are significant risk factors for major postoperative complications.
- Adverse outcomes, including reduced long-term survival, are associated with major complications after LG for GC.
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