Association between preoperative serum zinc level and prognosis in patients with advanced esophageal cancer in the neoadjuvant treatment era
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View abstract on PubMed
Summary
This summary is machine-generated.Preoperative low serum zinc levels negatively impact outcomes for advanced esophageal cancer patients undergoing neoadjuvant chemotherapy. Supplementation may be needed for patients with zinc deficiency to improve recurrence-free survival.
Area Of Science
- Oncology
- Nutritional Science
- Trace Element Metabolism
Background
- Zinc (Zn) is an essential trace element with known effects on cancer prognosis.
- The role of preoperative serum zinc levels in advanced esophageal cancer treated with neoadjuvant therapy is not well-defined.
Purpose Of The Study
- To investigate the association between preoperative serum zinc levels and patient outcomes in advanced esophageal cancer.
- To determine if preoperative zinc status influences survival and recurrence rates after neoadjuvant chemotherapy and surgery.
Main Methods
- Retrospective analysis of 185 advanced esophageal cancer patients who received neoadjuvant chemotherapy and R0 surgery.
- Patients were categorized into low (<64 μg/dL) and high (≥64 μg/dL) preoperative serum zinc groups.
- Outcomes including overall survival (OS) and recurrence-free survival (RFS) were analyzed.
Main Results
- Low preoperative serum zinc was associated with significantly worse 2-year OS (76.2% vs. 83.3%, p=0.044).
- In pathological non-responders, low zinc significantly correlated with shorter 2-year RFS (39.6% vs. 64.1%, p=0.032).
- Low BMI and low zinc levels were independent risk factors for worse RFS in non-responders.
Conclusions
- Preoperative low serum zinc levels adversely affect early recurrence in esophageal cancer patients post-neoadjuvant chemotherapy.
- Zinc supplementation should be considered for esophageal cancer patients with preoperative zinc deficiency.
- Monitoring and addressing zinc status may be crucial for improving treatment outcomes in this patient population.
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