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Updated: Jun 22, 2025

Acute Myocardial Infarction in Rats

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models.

Vipin Kumar Verma¹, Ekta Mutneja¹, Salma Malik¹

¹Cardiovascular Research Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India.

Oxidative Medicine and Cellular Longevity

|July 3, 2024

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This summary is machine-generated.

Abatacept (ABT) pretreatment improved heart function after myocardial infarction (MI) in rats by reducing inflammation and oxidative stress. This study highlights ABT

Area of Science:

Cardiology
Pharmacology
Immunology

Background:

Myocardial infarction (MI) causes irreversible heart damage due to ischemia/hypoxia.
Ischemia-reperfusion (IR) injury exacerbates damage through free radicals and inflammation.
Abatacept (ABT), an anti-inflammatory drug, is explored for cardioprotective effects.

Purpose of the Study:

To investigate the cardioprotective potential of Abatacept (ABT) in a rat model of myocardial ischemia-reperfusion (IR) injury.
To optimize the dosage of ABT for treating myocardial necrosis.
To elucidate the underlying mechanisms of ABT's cardioprotective effects.

Main Methods:

Dose optimization of ABT in a chemically induced myocardial necrosis model.
Surgical induction of myocardial IR injury in rats (n=30), randomized into five groups.

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Last Updated: Jun 22, 2025

Acute Myocardial Infarction in Rats

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Published on: February 16, 2011

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

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Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

Assessment of cardioprotective effects using hemodynamic, biochemical, histopathological, and molecular analyses.

Main Results:

21-day ABT pretreatment (5 mg/kg) significantly improved hemodynamic and ventricular functions in MI rats.
ABT inhibited MAP kinase signaling and modulated Nrf-2/HO-1 downstream signaling.
Cardioprotection was evidenced by reduced cardiac injury, inflammation, and oxidative stress markers.

Conclusions:

Abatacept (ABT) demonstrates significant cardioprotective effects against myocardial IR injury in a rat model.
ABT exerts its protective effects by modulating inflammatory and oxidative stress pathways.
This study supports the clinical application of ABT in mitigating inflammatory responses post-MI.