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Updated: Jun 22, 2025

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Hemodynamic Force Based on Cardiac Magnetic Resonance Imaging: State of the Art and Perspective
Yangzhen Hou1, Hui Zhou1, Yajuan Li1
1Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Insights
Hemodynamic force (HDF) offers a noninvasive method to assess cardiac function by analyzing intracardiac blood flow. This technique, using cardiac MRI, provides comprehensive data for evaluating heart health.
Area of Science:
- Cardiovascular imaging
- Biomedical engineering
- Cardiac physiology
Background:
- Intracardiac blood flow significantly influences cardiac morphology and function.
- Invasive catheterization is the traditional method for measuring intracardiac blood pressure, limiting its widespread application.
- Hemodynamic force (HDF) represents a novel approach to characterize cardiac function.
Purpose of the Study:
- To review the concept and parameters of Hemodynamic Force (HDF).
- To summarize current clinical applications of HDF in cardiac assessment.
- To discuss challenges and future directions for HDF research.
Main Methods:
- Noninvasive measurement of HDF using 4D flow cardiac MRI and cine cardiac MRI.
- Integration of intraventricular pressure gradients to calculate global intracavitary blood flow force.
- Analysis of the HDF time curve for qualitative and quantitative insights.
Main Results:
- HDF provides a comprehensive dataset for cardiac function analysis.
- Advances in MRI technology enable noninvasive HDF measurement.
- HDF parameters offer a promising tool for accurate cardiac characterization.
Conclusions:
- Hemodynamic force (HDF) is a valuable, noninvasive tool for assessing cardiac function.
- Further research into HDF is warranted to address current limitations and explore future clinical potential.
- HDF has the potential to enhance the understanding and management of cardiovascular diseases.
Abstract:
Intracardiac blood flow has long been proposed to play a significant role in cardiac morphology and function. However, absolute blood pressure within the heart has mainly been measured by invasive catheterization, which limits its application. Hemodynamic force (HDF) is the global force of intracavitary blood flow acquired by integrating the intraventricular pressure gradient over the entire ventricle and thus may be a promising tool for accurately characterizing cardiac function. Recent advances in magnetic resonance imaging technology allow for a noninvasive measurement of HDF through both 4D flow cardiac MRI and cine cardiac MRI. The HDF time curve provides comprehensive data for both qualitative and quantitative analysis. In this review, a series of HDF parameters is introduced and a summary of the current literature regarding HDF in clinical practice is presented. Additionally, the current dilemmas and future prospects are discussed in order to contribute to the future research. LEVEL OF EVIDENCE: 5. TECHNICAL EFFICACY: Stage 2.
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